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Vaccine. 2005 Jul 14;23(32):4110-9. Epub 2005 Apr 12.

Cost-effectiveness of universal childhood hepatitis A vaccination in Chile.

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  • 1School of Public Health, Faculty of Medicine, University of Chile, Santiago, Chile.


Hepatitis A is an important public health problem in Chile. Childhood vaccination has reduced hepatitis A rates in several countries, prompting this evaluation of its cost-effectiveness in Chile. Using a Markov model, we project mass vaccination would reduce hepatitis A cases among birth cohort members and their personal contacts >80%. Vaccination costs of US dollars 5.3-6.4 million would be offset by US dollars 9.2-9.4 million reductions in disease costs. Further, approximately 70 fatal infections would be averted and >4600 quality-adjusted life years would be saved. This analysis supports the cost-effectiveness of universal childhood hepatitis A vaccination in Chile.

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