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Transplant Proc. 2005 Jun;37(5):2032-6.

Campath-1H as rescue therapy for the treatment of acute rejection in kidney transplant patients.

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  • 1Division of Immunology and Organ Transplantation. The University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX 77030, USA.

Abstract

INTRODUCTION:

Kidney transplant patients with acute rejection episodes refractory to antilymphocyte preparations require aggressive treatment to salvage renal function and reduce the progression of chronic allograft nephropathy.

PATIENTS AND METHODS:

During a 6-month period, we administered Campath-1H as salvage therapy to five patients who had been previously treated with thymoglobulin and/or OKT3. In addition to measurements of the serum creatinine and BUN levels, we estimated creatinine clearance and glomerular filtration rates (GFR) using the Cockcroft-Gault and the MDRD equations at the time of initiation of therapy as well as at 2 weeks and 2 months thereafter.

RESULT:

Four of the five patients responded to Campath-1H therapy; kidney function improved to nearly the level before the rejection episode. The estimated creatinine clearance increased approximately threefold and the GFR approximately fourfold higher than the values before Campath-1H administration. The adverse events were mild and self-limited.

CONCLUSION:

Salvage of refractory acute rejection episodes may be possible in selected patients using Campath-1H.

PMID:
15964331
[PubMed - indexed for MEDLINE]
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