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Curr Opin Struct Biol. 2005 Jun;15(3):248-53.

Evolutionary aspects of whole-genome biology.

Author information

  • Department of Chemistry & Biochemistry, University of California San Diego, La Jolla, CA 92093-0314, USA. rdoolittle@ucsd.edu

Abstract

A decade of access to whole-genome sequences has been increasingly revealing about the informational network relating all living organisms. Although at one point there was concern that extensive horizontal gene transfer might hopelessly muddle phylogenies, it has not proved a severe hindrance. The melding of sequence and structural information is being used to great advantage, and the prospect exists that some of the earliest aspects of life on Earth can be reconstructed, including the invention of biosynthetic and metabolic pathways. Still, some fundamental phylogenetic problems remain, including determining the root--if there is one--of the historical relationship between Archaea, Bacteria and Eukarya.

PMID:
15963888
[PubMed - indexed for MEDLINE]
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