[Macrophage activation syndrome after treatment wi...[Presse Med. 2005]

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1: Presse Med. 2005 Apr 23;34(8):583-4.Links

[Macrophage activation syndrome after treatment with infliximab for fistulated Crohn's disease]

[Article in French]

Chauveau E, Terrier F, Casassus-Buihle D, Moncoucy X, Oddes B.

Service des maladies digestives et tropicales, Hôpital d'Instruction des Armées Robert Picqué 33998 Bordeaux Armées.

INTRODUCTION: Macrophage activation syndrome has never been reported as an adverse effect of infliximab. CASE: Treatment with infliximab was prescribed for a 37-year-old man with fistulated Crohn's disease unresponsive to azathioprine. Three months after the last injection, he developed macrophagic activation syndrome, with febrile pancytopenia, hyperferritinemia, hypertriglyceridemia and an activated cephalin time twice the control level. DISCUSSION: Elimination of the known causes of macrophage activation syndrome suggests it is related to the infliximab treatment, but its pathogenesis remains a mystery.

PMID: 15962497 [PubMed - indexed for MEDLINE]

Effectiveness and tolerability of repeated treatment with infliximab in patients with Crohn's disease: a retrospective data analysis in Germany. [Int J Colorectal Dis. 2005]
Increased production of granulocyte-macrophage colony-stimulating factor in Crohn's disease--a possible target for infliximab treatment. [Eur J Gastroenterol Hepatol. 2004]
Review[Indications and results of infliximab in Crohn's disease] [Tunis Med. 2004]
Use of infliximab in the treatment of Crohn's disease in children and adolescents. [J Pediatr Gastroenterol Nutr. 2001]
ReviewGuidelines for treatment with infliximab for Crohn's disease. [Neth J Med. 2006]

Patient Drug Information

Azathioprine (Azasan®, Imuran®) Azathioprine is used with other medications to prevent rejection of kidney transplants. It is also used to treat severe rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain and swellin...

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Infliximab Injection (Remicade®) Pending revision, the material in this section should be considered in light of more recently available information in the MedWatch notification at the beginning of this monograph.

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[Macrophage activation syndrome after treatment with infliximab for fistulated Crohn's disease]

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