Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Physiol. 2005 Aug 15;567(Pt 1):53-8. Epub 2005 Jun 16.

TRPV4 plays an evolutionary conserved role in the transduction of osmotic and mechanical stimuli in live animals.

Author information

  • Center for Translational Neuroscience, Duke University Medical Center, Box 2900, Durham, NC 27710, USA. wolfgang@neuro.duke.edu

Abstract

The TRPV4 ion channel, previously named vanilloid receptor-related osmotically activated channel (VR-OAC), functions in vivo in the transduction of osmotic and mechanical stimuli. In trpv4 null mice, TRPV4 was found to be necessary for the maintenance of systemic osmotic equilibrium, and for normal thresholds in response to noxious mechanical stimuli. In a Caenorhabditis elegans TRPV mutant transgenic for mammalian TRPV4, the mammalian transgene was directing the osmotic and mechanical avoidance response in the context of the ASH 'nociceptive' neurone. Molecular mechanisms of gating of TRPV4 in vivo are not known at this point and have to be determined.

PMID:
15961428
[PubMed - indexed for MEDLINE]
PMCID:
PMC1474158
Free PMC Article

Images from this publication.See all images (1)Free text

Figure 1
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk