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1: Bioorg Med Chem Lett. 2005 Jul 15;15(14):3374-9.Click here to read Links

Rhodanine derivatives as inhibitors of JSP-1.

Cutshall NS, O'Day C, Prezhdo M.

Ceptyr Inc., 3830 Monte Villa Parkway, Suite 200, Bothell, WA 98021, USA. ncutshall@ceptyr.com

Dual-specificity phosphatases (DSPs) are a subclass within the protein tyrosine phosphatase family (PTPs). A series of rhodanine-based inhibitors was synthesized and shown to be novel, potent, and selective inhibitors against the DSP family member JNK-stimulating phosphatase-1 (JSP-1). Compounds of this class may be useful for the treatment of inflammatory and proliferative disorders.

PMID: 15961311 [PubMed - indexed for MEDLINE]