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Genome Biol. 2005;6(6):221. Epub 2005 May 27.

Making sense of nonsense: the evolution of selenocysteine usage in proteins.

Author information

  • Department of Molecular Genetics, Microbiology and Immunology, UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA. paul.copeland@umdnj.edu

Abstract

A recent analysis of sequences derived from organisms in the Sargasso Sea has revealed a surprisingly different set of selenium-containing proteins than that previously found in sequenced genomes and suggests that selenocysteine utilization has been lost by many groups of organisms during evolution.

PMID:
15960811
[PubMed - indexed for MEDLINE]
PMCID:
PMC1175963
Free PMC Article

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