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    Genome Biol. 2005;6(6):221. Epub 2005 May 27.

    Making sense of nonsense: the evolution of selenocysteine usage in proteins.

    Copeland PR.

    Department of Molecular Genetics, Microbiology and Immunology, UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA. paul.copeland@umdnj.edu

    A recent analysis of sequences derived from organisms in the Sargasso Sea has revealed a surprisingly different set of selenium-containing proteins than that previously found in sequenced genomes and suggests that selenocysteine utilization has been lost by many groups of organisms during evolution.

    PMID: 15960811 [PubMed - indexed for MEDLINE]

    PMCID: PMC1175963

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