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Genome Biol. 2005;6(6):113. Epub 2005 May 31.

Histone modifications: from genome-wide maps to functional insights.

Author information

  • 1Netherlands Cancer Institute, Plesmanlaan 121,1066 CX Amsterdam, The Netherlands.

Abstract

A large number of histone modifications has been implicated in the regulation of gene expression. Together, these modifications have the potential to form a complex combinatorial regulatory code. Genome-wide mapping approaches provide new opportunities to decipher this code, but they may suffer from systematic biases. Integration of datasets and improved technologies will provide the way forward.

PMID:
15960810
[PubMed - indexed for MEDLINE]
PMCID:
PMC1175962
Free PMC Article

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