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1: Genome Biol. 2005;6(6):113. Epub 2005 May 31.Click here to read Click here to read Links

Histone modifications: from genome-wide maps to functional insights.

van Leeuwen F, van Steensel B.

Netherlands Cancer Institute, Plesmanlaan 121,1066 CX Amsterdam, The Netherlands.

A large number of histone modifications has been implicated in the regulation of gene expression. Together, these modifications have the potential to form a complex combinatorial regulatory code. Genome-wide mapping approaches provide new opportunities to decipher this code, but they may suffer from systematic biases. Integration of datasets and improved technologies will provide the way forward.

PMID: 15960810 [PubMed - indexed for MEDLINE]

PMCID: PMC1175962