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Chem Commun (Camb). 2005 Jun 21;(23):2909-11. Epub 2005 Jun 21.

The use of a continuous flow-reactor employing a mixed hydrogen-liquid flow stream for the efficient reduction of imines to amines.

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  • 1Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UKCB2 1EW.


Imines have been reduced to amines in high yield, and with excellent chemoselectivity, by catalytic hydrogenation in a continuous flow-reactor, utilising an electrochemically-generated hydrogen source to produce a mixed hydrogen-liquid flow stream.

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