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Am J Clin Pathol. 1992 Jun;97(6):806-9.

Papillary adenofibroma of the uterus. Report of a case involved by adenocarcinoma and review of the literature.

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  • 1Department of Pathology, Akron City Hospital, Ohio.


An unusual case of uterine papillary adenofibroma involved by an invasive well-differentiated adenocarcinoma is reported. The diagnosis was established using a hysterectomy specimen from a 68-year-old woman who was initially examined for abdominal pain and vaginal bleeding. The tumor was a broad-based polypoid mass composed of papillary projections into clefts and cysts. These papillations were covered by a variety of epithelial types and focally involved by an infiltrating adenocarcinoma. The stroma was fibrous and collagenized with variable numbers of benign fibroblasts. The papillary adenofibroma is considered to be a benign mixed tumor of Müllerian origin. Fifteen other cases of uterine adenofibroma have been reported in the literature and only one of these was focally involved by an adenocarcinoma. The clinical and histologic features of this rare disease are reviewed.

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