Abstract
It is well known that the products of chromosome replication are paired to ensure that the sisters segregate away from each other during mitosis. A key issue is how cells pair sister chromatids but preclude the catastrophic pairing of nonsister chromatids. The identification of both replication factor C and DNA helicases as critical for sister chromatid pairing has brought new insights into this fundamental process.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Cell Cycle Proteins / genetics
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Chromosomal Proteins, Non-Histone
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Chromosome Pairing / genetics*
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Chromosome Segregation / genetics*
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Cohesins
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DNA Helicases / genetics*
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DNA Replication / genetics
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DNA-Binding Proteins / genetics*
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Fungal Proteins / genetics
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Humans
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Mitosis / genetics*
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Models, Genetic
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Nuclear Proteins / genetics
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Replication Protein C
Substances
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Cell Cycle Proteins
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Chromosomal Proteins, Non-Histone
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DNA-Binding Proteins
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Fungal Proteins
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Nuclear Proteins
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DNA Helicases
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Replication Protein C