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Bioinformatics. 2005 Aug 15;21(16):3435-8. Epub 2005 Jun 14.

FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfolded.

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  • 1Biological Services, Weizmann Institute of Science, Rehovot 76100, Israel.

Abstract

An easy-to-use, versatile and freely available graphic web server, FoldIndex is described: it predicts if a given protein sequence is intrinsically unfolded implementing the algorithm of Uversky and co-workers, which is based on the average residue hydrophobicity and net charge of the sequence. FoldIndex has an error rate comparable to that of more sophisticated fold prediction methods. Sliding windows permit identification of large regions within a protein that possess folding propensities different from those of the whole protein.

PMID:
15955783
[PubMed - indexed for MEDLINE]
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