Mech Ageing Dev. 2005 Oct;126(10):1034-9.

Glycation, ageing and carnosine: are carnivorous diets beneficial?

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Centre for Experimental Therapeutics, William Harvey Research Institute, John Vane Science Centre, Bart's and the London Queen Mary's School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK. alanandjill@lineone.net

Abstract

Non-enzymic protein glycosylation (glycation) plays important roles in ageing and in diabetes and its secondary complications. Dietary constituents may play important roles in accelerating or suppressing glycation. It is suggested that carnivorous diets contain a potential anti-glycating agent, carnosine (beta-alanyl-histidine), whilst vegetarians may lack intake of the dipeptide. The possible beneficial effects of carnosine and related structures on protein carbonyl stress, AGE formation, secondary diabetic complications and age-related neuropathology are discussed.

PMID:: 15955546; [PubMed - indexed for MEDLINE]

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Carnosine

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Related citations in PubMed

Review Would carnosine or a carnivorous diet help suppress aging and associated pathologies? [Ann N Y Acad Sci. 2006]
Review Would carnosine or a carnivorous diet help suppress aging and associated pathologies?
Hipkiss AR. Ann N Y Acad Sci. 2006 May; 1067:369-74.
Review A possible new role for the anti-ageing peptide carnosine. [Cell Mol Life Sci. 2000]
Review A possible new role for the anti-ageing peptide carnosine.
Hipkiss AR, Brownson C. Cell Mol Life Sci. 2000 May; 57(5):747-53.
Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups. [Mech Ageing Dev. 2001]
Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups.
Hipkiss AR, Brownson C, Carrier MJ. Mech Ageing Dev. 2001 Sep 15; 122(13):1431-45.
Review Carnosine, a protective, anti-ageing peptide? [Int J Biochem Cell Biol. 1998]
Review Carnosine, a protective, anti-ageing peptide?
Hipkiss AR. Int J Biochem Cell Biol. 1998 Aug; 30(8):863-8.
Carnosine reacts with a glycated protein. [Free Radic Biol Med. 2000]
Carnosine reacts with a glycated protein.
Brownson C, Hipkiss AR. Free Radic Biol Med. 2000 May 15; 28(10):1564-70.

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Cited by 1 PubMed Central article

Energy metabolism, altered proteins, sirtuins and ageing: converging mechanisms? [Biogerontology. 2008]
Energy metabolism, altered proteins, sirtuins and ageing: converging mechanisms?
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