Neuroimage. 2005 Jul 1;26(3):839-51. Epub 2005 Apr 1.

Unified segmentation.

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Wellcome Department of Imaging Neuroscience, 12 Queen Square, London, WC1N 3BG, UK. john@fil.ion.ucl.ac.uk

Abstract

A probabilistic framework is presented that enables image registration, tissue classification, and bias correction to be combined within the same generative model. A derivation of a log-likelihood objective function for the unified model is provided. The model is based on a mixture of Gaussians and is extended to incorporate a smooth intensity variation and nonlinear registration with tissue probability maps. A strategy for optimising the model parameters is described, along with the requisite partial derivatives of the objective function.

PMID:: 15955494; [PubMed - indexed for MEDLINE]

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Research Support, Non-U.S. Gov't

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Grant Support

Wellcome Trust/United Kingdom

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