Acta Psychiatr Scand. 1992 Apr;85(4):292-4.

Treatment resistance of depression after head injury: a preliminary study of amitriptyline response.

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Department of Psychiatry, Trinity College Medical School, Dublin, Ireland.

Abstract

Thirteen patients with depression following minor head injury were matched with 13 functional depressives. Both groups were indistinguishable psychopathologically. Five of the functional group had a family history of affective disorder and none of the head-injury group had such a history. Both groups were treated with amitriptyline, beginning with 100 mg daily, increasing to a maximum of 250 mg/d. There were significant differences in response between the 2 groups, with only 4 of the head-injury patients improving. Our preliminary results suggest that this condition is relatively resistant to tricyclic therapy.

PMID:: 1595364; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

Amitriptyline

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AMITRIPTYLINE - HSDB

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