Nat Med. 2005 Jul;11(7):740-7. Epub 2005 Jun 12.

Smallpox vaccine-induced antibodies are necessary and sufficient for protection against monkeypox virus.

Edghill-Smith Y, Golding H, Manischewitz J, King LR, Scott D, Bray M, Nalca A, Hooper JW, Whitehouse CA, Schmitz JE, Reimann KA, Franchini G.

Source

Animal Models & Retroviral Vaccines Section, National Cancer Institute, 41/D804, Bethesda, Maryland 20892, USA.

Abstract

Vaccination with live vaccinia virus affords long-lasting protection against variola virus, the agent of smallpox. Its mode of protection in humans, however, has not been clearly defined. Here we report that vaccinia-specific B-cell responses are essential for protection of macaques from monkeypox virus, a variola virus ortholog. Antibody-mediated depletion of B cells, but not CD4+ or CD8+ T cells, abrogated vaccine-induced protection from a lethal intravenous challenge with monkeypox virus. In addition, passive transfer of human vaccinia-neutralizing antibodies protected nonimmunized macaques from severe disease. Thus, vaccines able to induce long-lasting protective antibody responses may constitute realistic alternatives to the currently available smallpox vaccine (Dryvax).

PMID:: 15951823; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Smallpox - MedlinePlus Health Information

Supplemental Content

Related citations

DNA/MVA HIV-1/AIDS vaccine elicits long-lived vaccinia virus-specific immunity and confers protection against a lethal monkeypox challenge. [Virology. 2007]
DNA/MVA HIV-1/AIDS vaccine elicits long-lived vaccinia virus-specific immunity and confers protection against a lethal monkeypox challenge.
Nigam P, Earl PL, Americo JL, Sharma S, Wyatt LS, Edghill-Spano Y, Chennareddi LS, Silvera P, Moss B, Robinson HL, et al. Virology. 2007 Sep 15; 366(1):73-83. Epub 2007 May 16.
Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox. [Nature. 2004]
Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox.
Earl PL, Americo JL, Wyatt LS, Eller LA, Whitbeck JC, Cohen GH, Eisenberg RJ, Hartmann CJ, Jackson DL, Kulesh DA, et al. Nature. 2004 Mar 11; 428(6979):182-5.
Smallpox vaccine does not protect macaques with AIDS from a lethal monkeypox virus challenge. [J Infect Dis. 2005]
Smallpox vaccine does not protect macaques with AIDS from a lethal monkeypox virus challenge.
Edghill-Smith Y, Bray M, Whitehouse CA, Miller D, Mucker E, Manischewitz J, King LR, Robert-Guroff M, Hryniewicz A, Venzon D, et al. J Infect Dis. 2005 Feb 1; 191(3):372-81. Epub 2005 Jan 4.
Review Immunity and immunological memory following smallpox vaccination. [Immunol Rev. 2006]
Review Immunity and immunological memory following smallpox vaccination.
Amanna IJ, Slifka MK, Crotty S. Immunol Rev. 2006 Jun; 211:320-37.
Review Monkeypox virus and insights into its immunomodulatory proteins. [Immunol Rev. 2008]
Review Monkeypox virus and insights into its immunomodulatory proteins.
Weaver JR, Isaacs SN. Immunol Rev. 2008 Oct; 225:96-113.

See reviews... See all...

Cited by 73 PubMed Central articles

Antibody against extracellular vaccinia virus (EV) protects mice through complement and Fc receptors. [PLoS One. 2011]
Antibody against extracellular vaccinia virus (EV) protects mice through complement and Fc receptors.
Cohen ME, Xiao Y, Eisenberg RJ, Cohen GH, Isaacs SN. PLoS One. 2011; 6(6):e20597. Epub 2011 Jun 8.
Establishment of the black-tailed prairie dog (Cynomys ludovicianus) as a novel animal model for comparing smallpox vaccines administered preexposure in both high- and low-dose monkeypox virus challenges. [J Virol. 2011]
Establishment of the black-tailed prairie dog (Cynomys ludovicianus) as a novel animal model for comparing smallpox vaccines administered preexposure in both high- and low-dose monkeypox virus challenges.
Keckler MS, Carroll DS, Gallardo-Romero NF, Lash RR, Salzer JS, Weiss SL, Patel N, Clemmons CJ, Smith SK, Hutson CL, et al. J Virol. 2011 Aug; 85(15):7683-98. Epub 2011 Jun 1.
Adverse events post smallpox-vaccination: insights from tail scarification infection in mice with Vaccinia virus. [PLoS One. 2011]
Adverse events post smallpox-vaccination: insights from tail scarification infection in mice with Vaccinia virus.
Mota BE, Gallardo-Romero N, Trindade G, Keckler MS, Karem K, Carroll D, Campos MA, Vieira LQ, da Fonseca FG, Ferreira PC, et al. PLoS One. 2011 Apr 15; 6(4):e18924. Epub 2011 Apr 15.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Smallpox vaccine-induced antibodies are necessary and sufficient for protection ...
Smallpox vaccine-induced antibodies are necessary and sufficient for protection against monkeypox virus.
Nat Med. 2005 Jul ;11(7):740-7. Epub 2005 Jun 12 .

PubMed
Home- versus hospital-laundered scrubs: a pilot study.
Home- versus hospital-laundered scrubs: a pilot study.
MCN Am J Matern Child Nurs. 2004 Mar-Apr ;29(2):106-10.

PubMed
Long-term effects of teaching behavioral strategies for managing persistent audi...
Long-term effects of teaching behavioral strategies for managing persistent auditory hallucinations in schizophrenia.
J Psychosoc Nurs Ment Health Serv. 2004 Jan ;42(1):18-27.

PubMed
Subarachnoid hemorrhage treated with clipping: long-term effects on employment, ...
Subarachnoid hemorrhage treated with clipping: long-term effects on employment, relationships, personality, and mood.
Neurosurgery. 2007 Jan ;60(1):91-7; discussion 97-8.

PubMed
Patient satisfaction and clinical outcomes after overnight orthokeratology.
Patient satisfaction and clinical outcomes after overnight orthokeratology.
Optom Vis Sci. 2009 Jul ;86(7):875-82.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Smallpox vaccine-induced antibodies are necessary and sufficient for protection against monkeypox virus.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Related citations

Cited by 73 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information