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Biochimie. 2005 Sep-Oct;87(9-10):805-11.

Translational control during mitosis.

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  • 1Equipe Cycle Cellulaire et DĂ©veloppement, UMR 7150 CNRS/UPMC, Station Biologique de Roscoff, BP 74, 29682 Roscoff cedex, France.

Abstract

Translation is now recognized as an important process in the regulation of gene expression. During the cell cycle, translation is tightly regulated. Protein synthesis is necessary for entry into and progression through mitosis and conversely, modifications of translational activity are observed during the cell cycle. This review focuses on translational control during mitosis (or M-phase) and the role of CDK1/cyclin B, the universal cell cycle regulator implicated in the G2/M transition, in protein synthesis regulation.

PMID:
15951098
[PubMed - indexed for MEDLINE]
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