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    Cell Death Differ. 2005 Dec;12(12):1601-12. Epub 2005 Jun 10.

    Bax limits adult neural stem cell persistence through caspase and IP3 receptor activation.

    Shi J, Parada LF, Kernie SG.

    Department of Pediatrics, UT Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390-9133, USA.

    Neural stem cells in the mammalian brain persist and are functional well into adulthood. There is, however, little insight into mechanisms that control adult neural stem cell survival. Mice deficient in the proapoptotic molecule Bax exhibit increased numbers of multipotent progenitor cells in the adult subventricular zone. In vitro, these progenitors behave as neural stem cells and utilize Bax and caspase activation to direct cell death. We demonstrate that the predominate mechanism underlying caspase and Bax-mediated adult neural stem cell death lies in the modulation of calcium flux through interaction with the IP3 receptor.

    PMID: 15947791 [PubMed - indexed for MEDLINE]

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