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Science. 2005 Jun 10;308(5728):1589-92.

Uterine fibroids: the elephant in the room.

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  • 1Department of Carcinogenesis, University of Texas and MD Anderson Cancer Center, Park Road 1C, Smithville, TX 78957, USA.


Uterine fibroids (leiomyomas) have historically been viewed as important chiefly as the major indication for hysterectomy. As new therapies are developed, the heterogeneity of this disease becomes therapeutically relevant. An awareness of the role of genetics, the extracellular matrix, and hormones in tumor etiology is key to understanding this disease.

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