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Hum Reprod. 2005 Aug;20(8):2325-9. Epub 2005 Jun 9.

Exposure to bisphenol A is associated with recurrent miscarriage.

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  • 1Department of Obstetrics and Gynecology, Nagoya City University Medical School, Nagoya, Japan.



Little is known about the influence of high exposure to bisphenol A on recurrent miscarriage and immunoendocrine abnormalities.


Serum bisphenol A, antiphospholipid antibodies (aPLs), antinuclear antibodies (ANAs), natural killer cell (NK) activity, prolactin, progesterone, thyroid-stimulating hormone (TSH) and free T4 were examined in 45 patients with a history of three or more (3-11) consecutive first-trimester miscarriages and 32 healthy women with no history of live birth and infertility. Subsequent pregnancy outcome and embryonic karyotype of abortuses were examined prospectively.


The mean+/-SD values for bisphenol A in patients were 2.59+/-5.23 ng/ml, significantly higher than the 0.77+/-0.38 ng/ml found for control women (P=0.024). High exposure to bisphenol A was associated with the presence of ANAs but not hypothyroidism, hyperprolactinaemia, luteal phase defects, NK cell activity or aPLs. A high level of bisphenol A in itself did not predict subsequent miscarriage.


Exposure to bisphenol A is associated with recurrent miscarriage.

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