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FEBS Lett. 2005 Jun 13;579(15):3355-61. Epub 2005 Apr 18.

Consistency of genome-based methods in measuring Metazoan evolution.

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  • 1EMBL Heidelberg, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.

Abstract

Seven distinct genome-wide divergence measures were applied pairwise to the nine sequenced animal genomes of human, mouse, rat, chicken, pufferfish, fruit fly, mosquito, and two nematode worms (Caenorhabditis briggsae and Caenorhabditis elegans). Qualitatively, all of these divergence measures are found to correlate with the estimated time since speciation; however, marked deviations are observed in a few lineages. The distinct genome divergence measures also correlate well among themselves, indicating that most of the processes shaping genomes are dominated by neutral events. The deviations from the clock-like scenario in some lineages are observed consistently by several measures, implicitly confirming their reliability.

PMID:
15943981
[PubMed - indexed for MEDLINE]
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