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FEBS Lett. 2005 Jun 13;579(15):3342-5. Epub 2005 Apr 18.

Linear motifs: evolutionary interaction switches.

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  • 1EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

Abstract

Linear motifs are short sequence patterns associated with a particular function. They differ fundamentally from longer, globular protein domains in terms of their binding affinities, evolution and in how they are found experimentally or computationally. In this Minireview, we discuss various aspects of these critically important functional regions.

PMID:
15943979
[PubMed - indexed for MEDLINE]
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