Pain. 1992 Apr;49(1):117-20.

Further evidence for the existence of long ascending unmyelinated primary afferent fibers within the dorsal funiculus: effects of capsaicin.

Source

Marine Biomedical Institute, University of Texas Medical Branch, Galveston 77550.

Abstract

The present study provides further evidence in support of the hypothesis that there is a fine primary afferent system in the dorsal funiculi by determining the effects of capsaicin (8-methyl-N-vanillyl-6-noneamide) on unmyelinated fibers in the cervical fasciculus gracilis of the rat. The neurolytic effect of this procedure was demonstrated by showing an 89% decrease in the number of unmyelinated fibers in the S2 dorsal roots of the experimental animals. Consequently, we feel that unmyelinated primary afferent fibers are largely removed from these animals. Neonatal administration of capsaicin (50 mg/kg) caused a 54% decrease in the number of unmyelinated fibers in the C3 fasciculus gracilis but no significant change in myelinated fiber numbers. The data provide further evidence for the existence of a significant primary afferent unmyelinated fiber system in the dorsal funiculus and suggest a role for the dorsal funiculi in the transmission of noxious information.

PMID:: 1594272; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Capsaicin

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

CAPSAICIN - HSDB

Supplemental Content

Save items

Related citations in PubMed

Ascending unmyelinated primary afferent fibers in the dorsal funiculus. [J Comp Neurol. 1989]
Ascending unmyelinated primary afferent fibers in the dorsal funiculus.
Patterson JT, Head PA, McNeill DL, Chung K, Coggeshall RE. J Comp Neurol. 1989 Dec 15; 290(3):384-90.
Primary afferent and propriospinal fibers in the rat dorsal and dorsolateral funiculi. [J Comp Neurol. 1987]
Primary afferent and propriospinal fibers in the rat dorsal and dorsolateral funiculi.
Chung K, Langford LA, Coggeshall RE. J Comp Neurol. 1987 Sep 1; 263(1):68-75.
Unmyelinated primary afferent fibers in dorsal funiculi of cat sacral spinal cord. [J Comp Neurol. 1985]
Unmyelinated primary afferent fibers in dorsal funiculi of cat sacral spinal cord.
Chung KS, Coggeshall RE. J Comp Neurol. 1985 Aug 15; 238(3):365-9.
Effect of neonatal capsaicin treatment on neural activity in the medullary dorsal horn of neonatal rats evoked by electrical stimulation to the trigeminal afferents: an optical, electrophysiological, and quantitative study. [Brain Res. 2001]
Effect of neonatal capsaicin treatment on neural activity in the medullary dorsal horn of neonatal rats evoked by electrical stimulation to the trigeminal afferents: an optical, electrophysiological, and quantitative study.
Takuma S. Brain Res. 2001 Jul 6; 906(1-2):1-12.
Review The morphological consequences of neonatal treatment with capsaicin on primary afferent neurones in adult rats. [Acta Physiol Hung. 1987]
Review The morphological consequences of neonatal treatment with capsaicin on primary afferent neurones in adult rats.
Lawson SN. Acta Physiol Hung. 1987; 69(3-4):315-21.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Further evidence for the existence of long ascending unmyelinated primary affere...
Further evidence for the existence of long ascending unmyelinated primary afferent fibers within the dorsal funiculus: effects of capsaicin.
Pain. 1992 Apr ;49(1):117-20.

PubMed
Carvedilol prevents cardiac hypertrophy and overexpression of hypoxia-inducible ...
Carvedilol prevents cardiac hypertrophy and overexpression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in pressure-overloaded rat heart.
J Biomed Sci. 2005 ;12(2):409-20.

PubMed
Do patients with primary fibromyalgia have an altered muscle sympathetic nerve a...
Do patients with primary fibromyalgia have an altered muscle sympathetic nerve activity?
Pain. 1992 Mar ;48(3):371-5.

PubMed
Comparing the global mRNA expression profile of human atrial and ventricular myo...
Comparing the global mRNA expression profile of human atrial and ventricular myocardium with high-density oligonucleotide arrays.
J Thorac Cardiovasc Surg. 2005 Jun ;129(6):1383-90.

PubMed
Does reporting of coronary artery bypass grafting from administrative databases ...
Does reporting of coronary artery bypass grafting from administrative databases accurately reflect actual clinical outcomes?
J Thorac Cardiovasc Surg. 2005 Jun ;129(6):1309-17.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: