Cells Tissues Organs. 2005;179(1-2):66-72.

Hyaluronan: a critical component of epithelial-mesenchymal and epithelial-carcinoma transitions.

Toole BP, Zoltan-Jones A, Misra S, Ghatak S.

Source

Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC 29425, USA. toolebp@musc.edu

Abstract

Hyaluronan plays a central role in the transition of epithelia to mesenchyme in the embryo and in the acquisition of transformed properties in carcinoma cells. In some cases, hyaluronan is both essential and sufficient for induction of epithelial-mesenchymal transitions (EMTs). Underlying its role are the effects of hyaluronan on receptor kinase activities, cell survival pathways, and multidrug transporters. A more complete understanding of the mechanisms whereby hyaluronan exerts its influences on cell behavior will enhance our understanding of normal and pathological EMTs and may lead to improved therapies for cancer patients.

PMID:: 15942194; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

HYALURONIC ACID - HSDB

Supplemental Content

Icon for S. Karger AG, Basel, Switzerland

Save items

Related citations in PubMed

Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells. [J Biol Chem. 2003]
Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells.
Zoltan-Jones A, Huang L, Ghatak S, Toole BP. J Biol Chem. 2003 Nov 14; 278(46):45801-10. Epub 2003 Sep 3.
Review Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin. [Cells Tissues Organs. 2005]
Review Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin.
Brabletz T, Hlubek F, Spaderna S, Schmalhofer O, Hiendlmeyer E, Jung A, Kirchner T. Cells Tissues Organs. 2005; 179(1-2):56-65.
Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells. [J Biol Chem. 2008]
Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells.
Misra S, Obeid LM, Hannun YA, Minamisawa S, Berger FG, Markwald RR, Toole BP, Ghatak S. J Biol Chem. 2008 May 23; 283(21):14335-44. Epub 2008 Mar 7.
The PDZ domains of zonula occludens-1 induce an epithelial to mesenchymal transition of Madin-Darby canine kidney I cells. Evidence for a role of beta-catenin/Tcf/Lef signaling. [J Biol Chem. 2000]
The PDZ domains of zonula occludens-1 induce an epithelial to mesenchymal transition of Madin-Darby canine kidney I cells. Evidence for a role of beta-catenin/Tcf/Lef signaling.
Reichert M, Müller T, Hunziker W. J Biol Chem. 2000 Mar 31; 275(13):9492-500.
Review beta-Catenin: a pivot between cell adhesion and Wnt signalling. [Curr Biol. 2005]
Review beta-Catenin: a pivot between cell adhesion and Wnt signalling.
Bienz M. Curr Biol. 2005 Jan 26; 15(2):R64-7.

See reviews... See all...

Cited by 7 PubMed Central articles

Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity. [J Biol Chem. 2011]
Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity.
Heise RL, Stober V, Cheluvaraju C, Hollingsworth JW, Garantziotis S. J Biol Chem. 2011 May 20; 286(20):17435-44. Epub 2011 Mar 11.
Review Hyaluronan as an immune regulator in human diseases. [Physiol Rev. 2011]
Review Hyaluronan as an immune regulator in human diseases.
Jiang D, Liang J, Noble PW. Physiol Rev. 2011 Jan; 91(1):221-64.
Synthesis and organization of hyaluronan and versican by embryonic stem cells undergoing embryoid body differentiation. [J Histochem Cytochem. 2010]
Synthesis and organization of hyaluronan and versican by embryonic stem cells undergoing embryoid body differentiation.
Shukla S, Nair R, Rolle MW, Braun KR, Chan CK, Johnson PY, Wight TN, McDevitt TC. J Histochem Cytochem. 2010 Apr; 58(4):345-58. Epub 2009 Dec 21.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Hyaluronan: a critical component of epithelial-mesenchymal and epithelial-carcin...
Hyaluronan: a critical component of epithelial-mesenchymal and epithelial-carcinoma transitions.
Cells Tissues Organs. 2005 ;179(1-2):66-72.

PubMed
Urban sprawl and risk for being overweight or obese.
Urban sprawl and risk for being overweight or obese.
Am J Public Health. 2004 Sep ;94(9):1574-9.

PubMed
Barriers to buying healthy foods for people with diabetes: evidence of environme...
Barriers to buying healthy foods for people with diabetes: evidence of environmental disparities.
Am J Public Health. 2004 Sep ;94(9):1549-54.

PubMed
Making America fit and trim--steps big and small.
Making America fit and trim--steps big and small.
Am J Public Health. 2004 Sep ;94(9):1478-9.

PubMed
Spinal fusion for back pain: a clinical and radiological review.
Spinal fusion for back pain: a clinical and radiological review.
J Spinal Disord. 1992 Mar ;5(1):32-38.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Hyaluronan: a critical component of epithelial-mesenchymal and epithelial-carcinoma transitions.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 7 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information