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J Rheumatol. 2005 Jun;32(6):1164-7.

Persistent cryoglobulinemic vasculitis following successful treatment of hepatitis C virus.

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  • 1Rheumatology and Clinical Immunology Division, University of Vermont College of Medicine, Burlington, Vermont 05405, USA.


There is a well established link between type II mixed cryoglobulinemia (MC) and hepatitis C virus (HCV) infection, and HCV is believed to be the cause of cryoprotein formation and tissue deposition. Successful treatment of HCV infection has resulted in resolution of cryoglobulinemia and vasculitis. We describe 4 patients who had persistent MC and vasculitis despite successful eradication of HCV with antiviral therapy.

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