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Arch Virol. 2005 Sep;150(9):1693-713. Epub 2005 Jun 3.

Hantavirus nucleocapsid protein: a multifunctional molecule with both housekeeping and ambassadorial duties.

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  • 1Department of Virology, Haartman Institute, University of Helsinki, Finland.


In recent years important progress has been made studying the nucleocapsid (N) protein of hantaviruses. The N protein presents a good example of a multifunctional viral macromolecule. It is a major structural component of a virion that encapsidates viral RNA (vRNA). It also interacts with the virus polymerase (L protein) and one of the glycoproteins. On top of these "house keeping" duties, the N protein performs interactive "ambassadorial" functions interfering with important regulatory pathways in the infected cells.

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