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BMJ. 2005 Jun 25;330(7506):1482. Epub 2005 Jun 1.

Long term effects of hysterectomy on mortality: nested cohort study.

Author information

  • 1Department of General Practice and Primary Care, University of Aberdeen, Foresterhill Health Centre, Aberdeen AB25 2AY. l.iversen@abdn.ac.uk

Abstract

OBJECTIVES:

To investigate the long term risk (mean > 20 years) of death from all causes, cardiovascular disease, and cancer in women who had or had not had a hysterectomy.

DESIGN:

Nested cohort study.

SETTING:

Royal College of General Practitioners' oral contraception study.

PARTICIPANTS:

7410 women (3705 flagged at the NHS central registries for cancer and death who had a hysterectomy during the oral contraception study and 3705 who were flagged but did not have the operation).

MAIN OUTCOME MEASURES:

Mortality from all causes, cardiovascular disease, and cancer.

RESULTS:

623 (8.4%) women had died by the end of follow-up (308 in the hysterectomy group and 315 in the non-hysterectomy group). Older women who had had a hysterectomy had a 6% reduced risk of death compared with women of a similar age who did not have the operation (adjusted hazard ratio 0.94, 95% confidence interval 0.75 to 1.18). Compared with young women who did not have a hysterectomy those who were younger at hysterectomy had an adjusted hazard ratio for all cause mortality of 0.82 (0.65 to 1.03). Hysterectomy was not associated with a significantly altered risk of mortality from cardiovascular disease or cancer regardless of age.

CONCLUSION:

Hysterectomy did not increase the risk of death in the medium to long term.

Comment in

PMID:
15930026
[PubMed - indexed for MEDLINE]
PMCID:
PMC558457
Free PMC Article
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