Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nat Rev Mol Cell Biol. 2005 Jun;6(6):487-98.

CLIPs and CLASPs and cellular dynamics.

Author information

  • 1Department of Cell Biology and Genetics, Erasmus Medical Centre, P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands. n.galjart@erasmusmc.nl

Abstract

The dynamic properties of microtubules are regulated by plus-end tracking proteins (+TIPs), which associate with the distal ends of microtubules. Among the +TIPs are cytoplasmic linker proteins (CLIPs), which promote microtubule growth and regulate dynein-dynactin localization, and CLIP-associating proteins (CLASPs), which stabilize specific subsets of microtubules on reception of signalling cues. CLIPs and CLASPs interact and cooperate to direct the microtubule network, thereby regulating cellular asymmetry.

PMID:
15928712
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk