Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nat Rev Immunol. 2005 Jun;5(6):472-84.

NFAT proteins: key regulators of T-cell development and function.

Author information

  • Albert Einstein College of Medicine, Department of Pathology, 1300 Morris Park Avenue, Bronx, New York 10461, USA. fmacianj@aecom.yu.edu

Abstract

Since the discovery of the first nuclear factor of activated T cells (NFAT) protein more than a decade ago, the NFAT family of transcription factors has grown to include five members. It has also become clear that NFAT proteins have crucial roles in the development and function of the immune system. In T cells, NFAT proteins not only regulate activation but also are involved in the control of thymocyte development, T-cell differentiation and self-tolerance. The functional versatility of NFAT proteins can be explained by their complex mechanism of regulation and their ability to integrate calcium signalling with other signalling pathways. This Review focuses on the recent advances in our understanding of the regulation, mechanism of action and functions of NFAT proteins in T cells.

PMID:
15928679
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk