STUDY OBJECTIVE: To evaluate the effectiveness of a program in which pharmacists screened at-risk patients for peripheral arterial disease using a handheld doppler device. DESIGN: Prospective study. SETTING: Primary care and consultative outpatient clinic. PATIENTS: Forty-one physician-referred patients older than 55 years who had no documented history of peripheral arterial disease. INTERVENTION: The pharmacists administered the San Diego Claudication Questionnaire and performed doppler examinations to calculate ankle-to-brachial indexes (ABIs). Patients with symptoms of claudication or with an ABI of 0.9 or less were considered to have possible peripheral arterial disease. Each diagnosis was confirmed by a physician. These patients were either referred for further evaluation, provided with immediate treatment, or told to continue their current drug regimen, if appropriate. MEASUREMENTS AND MAIN RESULTS: Eight (19.5%) of the 41 patients were diagnosed with peripheral arterial disease. Antiplatelet therapy was started in five patients, and one patient was referred to a vascular specialist. CONCLUSION: This pharmacist-initiated program effectively detected peripheral arterial disease in previously unscreened patients.