Format

Send to:

Choose Destination
See comment in PubMed Commons below
Kobe J Med Sci. 2004;50(3-4):101-9.

Molecular signals of Mammalian circadian clock.

Author information

  • 1Division of Molecular Brain Science, Department of Brain Sciences, Kobe University Graduate School of Medicine, Kobe, Japan.

Abstract

The circadian rhythm is originally generated by a transcription-translation based oscillatory loop composed of a set of clock genes in most organisms. The clock gene oscillation is generated by the core loop in each neuron of the hypothalamic suprachiasmatic nucleus. Phosphorylation and ubiquitination of clock proteins play the crucial role for the rhythmic transcription of clock genes. The core clock oscillation is conducted at the cellular levels by E-box or by D-box of clock controlled genes.

PMID:
15925944
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Kobe University School of Medicine
    Loading ...
    Write to the Help Desk