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BJOG. 2005 Jun;112(6):710-2.

Developmental toxicity of the angiotensin II type 1 receptor antagonists during human pregnancy: a report of 10 cases.

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  • 1Department of Pediatric Pharmacology and Pharmacogenetics, Hôpital Robert Debré, Paris, France.

Abstract

OBJECTIVE:

Angiotensin II type 1 receptor antagonists (ARA). Interacted with the renin-angiotensin system, and the present study was undertaken to examine their fetal and neonatal toxicity when taken by the mother during pregnancy.

DESIGN:

Prospective follow up of pregnant women exposed to an ARA during early pregnancy.

SETTING:

The present study was conducted in the departments of Paedriatric Pharmacology of the University hospital Robert Debre in Paris, France.

POPULATION:

Ten women exposed to an ARA during early pregnancy.

METHODS:

Prospective follow up.

MAIN OUTCOME MEASURE:

Fetal ultrasonography and outcome of pregnancy.

RESULTS:

Prenatal ultrasonography showed abnormal features in five cases (oligoamnios related to fetal tabular dysgenesis, fetal dysmorphia and renal abnormalities). Outcome of pregnancy was as follows: three induced abortions, two stillbirths (twin pregnancy), one neonate presenting with dysmorphia and renal disease and five neonates with an uneventful development.

CONCLUSION:

Women of reproductive age should be advised of the possible hazards of ARA and treatment should be stopped as soon as pregnany has been documented.

PMID:
15924524
[PubMed - indexed for MEDLINE]
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