Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Int J Hematol. 2005 May;81(4):281-7.

Of mice, flies, and man: the emerging role of polycomb-group genes in human malignant lymphomas.

Author information

  • Department of Pathology, VU Medical Center, 1081 HV Amsterdam, The Netherlands. fm.raaphorst@vumc.nl

Abstract

Genes belonging to the Polycomb group (PcG) are responsible for the maintenance of cell identity and are directly involved in epigenetic gene silencing. They perform a vital role in the regulation of embryogenesis but also contribute to various adult processes, including regulation of the cell cycle and lymphopoiesis. Experimental model systems have demonstrated that enhanced expression of individual PcG genes, such as Bmi1, results in the development of B-cell and T-cell lymphomas. In humans, a growing body of work has now linked human PcG genes to various hematologic and epithelial cancers. This review focuses on the emerging role of PcG genes in the development of human malignant lymphomas.

PMID:
15914355
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk