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Antigen receptors on B lymphocytes.
Max-Planck-Institut für Immunobiologie, Freiberg, Germany.
Recent studies on the structure of the B cell antigen receptor demonstrate that the membrane-bound and antigen-binding immunoglobulin molecules are noncovalently associated with a heterodimer of two novel transmembrane proteins. The B cell antigen receptor is thus a multicomponent receptor complex whose structural features are similar to those of the T cell antigen receptor complex. Cross-linking of the B cell antigen receptor results in rapid tyrosine phosphorylation of substrate proteins. This suggests that the B cell receptor belongs to a subgroup of the tyrosine kinase receptor family with a noncovalently associated src-like tyrosine kinase.
PMID: 1591006 [PubMed - indexed for MEDLINE]
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Cited by 48 PubMed Central articles
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[Dev Comp Immunol. 2008]
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[J Exp Med. 2007]
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Kitaura Y, Jang IK, Wang Y, Han YC, Inazu T, Cadera EJ, Schlissel M, Hardy RR, Gu H.
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[Immunity. 2007]
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