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Nat Genet. 2005 Jun;37(6):590-2. Epub 2005 May 22.

A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.

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  • 1The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

Abstract

We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.

PMID:
15908952
[PubMed - indexed for MEDLINE]
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