Osteoarthritis Cartilage. 2005 Oct;13(10):942-3.

Smoking and osteoarthritis: differential effect of nicotine on human chondrocyte glycosaminoglycan and collagen synthesis.

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Maricopa Medical Center Orthopaedic Residency Program, Phoenix, AZ 85006, USA.

Abstract

Anecdotal suggestions and retrospective studies indicate an inverse relationship between the incidence of osteoarthritis and individuals who smoke. As a possible explanation, our studies confirm that nicotine upregulates glycosaminoglycan and collagen synthetic activity of articular chondrocytes at physiological levels seen in individuals who smoke.

PMID:: 15908236; [PubMed - indexed for MEDLINE]

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