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    J Immunol. 2005 Jun 1;174(11):6967-73.

    The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes.

    Zhang N, He YW.

    Source

    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.

    Abstract

    The antiapoptotic protein Bcl-x(L) is induced in activated T lymphocytes upon costimulation through CD28, 4-1BB, and OX40. Bcl-x(L) is also highly enriched in memory T lymphocytes. Based on this body of evidence, it was thought that Bcl-x(L) plays an essential role in the generation of effector and memory T lymphocytes. We report that mice with a conditional deletion of Bcl-x in T lymphocytes develop a normal CD8(+) T cell response to Listeria monocytogenes infection. Furthermore, Bcl-x conditional knockout mice exhibit normal T-dependent humoral immune responses. These results indicate that Bcl-x is dispensable for the generation of effector and memory T lymphocytes and suggest that costimulation of T lymphocytes promotes their survival through a Bcl-x(L) independent mechanism.

    PMID:
    15905539
    [PubMed - indexed for MEDLINE]
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