Phys Rev Lett. 2005 May 6;94(17):178103. Epub 2005 May 5.

Divergence and Shannon information in genomes.

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Department of Physics, National Central University, Chungli, Taiwan 320, Republic of China.

Abstract

Shannon information (SI) and its special case, divergence, are defined for a DNA sequence in terms of probabilities of chemical words in the sequence and are computed for a set of complete genomes highly diverse in length and composition. We find the following: SI (but not divergence) is inversely proportional to sequence length for a random sequence but is length independent for genomes; the genomic SI is always greater and, for shorter words and longer sequences, hundreds to thousands times greater than the SI in a random sequence whose length and composition match those of the genome; genomic SIs appear to have word-length dependent universal values. The universality is inferred to be an evolution footprint of a universal mode for genome growth.

PMID:: 15904339; [PubMed - indexed for MEDLINE]

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