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Am J Hum Genet. 2005 Jul;77(1):140-8. Epub 2005 May 18.

Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia.

Author information

  • 1Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.

Abstract

Androgenetic alopecia (AGA), or male-pattern baldness, is the most common form of hair loss. Its pathogenesis is androgen dependent, and genetic predisposition is the major requirement for the phenotype. We demonstrate that genetic variability in the androgen receptor gene (AR) is the cardinal prerequisite for the development of early-onset AGA, with an etiological fraction of 0.46. The investigation of a large number of genetic variants covering the AR locus suggests that a polyglycine-encoding GGN repeat in exon 1 is a plausible candidate for conferring the functional effect. The X-chromosomal location of AR stresses the importance of the maternal line in the inheritance of AGA.

PMID:
15902657
[PubMed - indexed for MEDLINE]
PMCID:
PMC1226186
Free PMC Article

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