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1: Exp Neurol. 2005 Jul;194(1):284-7.Click here to read Links

Differential effects of endocannabinoids on [(3)H]-GABA uptake in the rat globus pallidus.

Venderova K, Brown TM, Brotchie JM.

Toronto Western Research Institute, Toronto Western Hospital, 399 Bathurst Street, MC 11-419, Toronto, Ontario, Canada M5T 258. venderova@yahoo.com

In the globus pallidus, cannabinoid CB(1) receptors are localized pre-synaptically on GABAergic neurons. We assessed the influence of the endocannabinoids, anandamide, 2-arachidonoyl-glycerol (2-AG) and noladin ether, on the uptake of [(3)H]-GABA in pallidal slices from rat. Both 2-AG and noladin ether increased [(3)H]-GABA uptake (by 40.8 +/- 8.0% and 38.4 +/- 12.5%). The effect of 2-AG was blocked by the cannabinoid CB(1) receptor antagonist AM 251. In contrast, neither anandamide nor the agonist WIN 55,212-2 had an effect on [(3)H]-GABA uptake. Different roles might be played by different endocannabinoids, both physiologically and in basal ganglia disorders, such as Parkinson's disease.

PMID: 15899265 [PubMed - indexed for MEDLINE]