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Am J Hum Genet. 2005 Jul;77(1):64-77. Epub 2005 May 16.

Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels.

Author information

  • 1Department of Genome Sciences, University of Washington, Seattle, WA, USA. csc47@u.washington.edu

Erratum in

  • Am J Hum Genet. 2008 Jan;82(1):251.

Abstract

Elevated plasma levels of C-reactive protein (CRP), an inflammation-sensitive marker, have emerged as an important predictor of future cardiovascular disease and metabolic abnormalities in apparently healthy men and women. Here, we performed a systematic survey of common nucleotide variation across the genomic region encompassing the CRP gene locus. Of the common single-nucleotide polymorphisms (SNPs) identified, several in the CRP promoter region are strongly associated with CRP levels in a large cohort study of cardiovascular risk in European American and African American young adults. We also demonstrate the functional importance of these SNPs in vitro.

PMID:
15897982
[PubMed - indexed for MEDLINE]
PMCID:
PMC1226195
Free PMC Article
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