Science. 1992 May 15;256(5059):1021-5.

Synaptotagmin: a calcium sensor on the synaptic vesicle surface.

Brose N, Petrenko AG, Südhof TC, Jahn R.

Source

Department of Neurochemistry, Max-Planck-Institute for Psychiatry, Martinsried, Germany.

Abstract

Neurons release neurotransmitters by calcium-dependent exocytosis of synaptic vesicles. However, the molecular steps transducing the calcium signal into membrane fusion are still an enigma. It is reported here that synaptotagmin, a highly conserved synaptic vesicle protein, binds calcium at physiological concentrations in a complex with negatively charged phospholipids. This binding is specific for calcium and involves the cytoplasmic domain of synaptotagmin. Calcium binding is dependent on the intact oligomeric structure of synaptotagmin (it is abolished by proteolytic cleavage at a single site). These results suggest that synaptotagmin acts as a cooperative calcium receptor in exocytosis.

PMID:: 1589771; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Molecular Biology Databases

CALCIUM, ELEMENTAL - HSDB

Supplemental Content

Save items

Related citations in PubMed

Binding of synaptotagmin to the alpha-latrotoxin receptor implicates both in synaptic vesicle exocytosis. [Nature. 1991]
Binding of synaptotagmin to the alpha-latrotoxin receptor implicates both in synaptic vesicle exocytosis.
Petrenko AG, Perin MS, Davletov BA, Ushkaryov YA, Geppert M, Südhof TC. Nature. 1991 Sep 5; 353(6339):65-8.
Synaptotagmins in membrane traffic: which vesicles do the tagmins tag? [Biochimie. 2000]
Synaptotagmins in membrane traffic: which vesicles do the tagmins tag?
Marquèze B, Berton F, Seagar M. Biochimie. 2000 May; 82(5):409-20.
synaptotagmin mutants reveal essential functions for the C2B domain in Ca2+-triggered fusion and recycling of synaptic vesicles in vivo. [J Neurosci. 2001]
synaptotagmin mutants reveal essential functions for the C2B domain in Ca2+-triggered fusion and recycling of synaptic vesicles in vivo.
Littleton JT, Bai J, Vyas B, Desai R, Baltus AE, Garment MB, Carlson SD, Ganetzky B, Chapman ER. J Neurosci. 2001 Mar 1; 21(5):1421-33.
Review Interactions between presynaptic calcium channels and proteins implicated in synaptic vesicle trafficking and exocytosis. [J Bioenerg Biomembr. 1998]
Review Interactions between presynaptic calcium channels and proteins implicated in synaptic vesicle trafficking and exocytosis.
Seagar M, Takahashi M. J Bioenerg Biomembr. 1998 Aug; 30(4):347-56.
Review p65-Synaptotagmin: a docking-fusion protein in synaptic vesicle exocytosis? [Neuroscience. 1993]
Review p65-Synaptotagmin: a docking-fusion protein in synaptic vesicle exocytosis?
Popoli M. Neuroscience. 1993 May; 54(2):323-8.

See reviews... See all...

Cited by over 100 PubMed Central articles

Analysis of Synaptotagmin, SV2, and Rab3 Expression in Cortical Glutamatergic and GABAergic Axon Terminals. [Front Cell Neurosci. 2011]
Analysis of Synaptotagmin, SV2, and Rab3 Expression in Cortical Glutamatergic and GABAergic Axon Terminals.
Bragina L, Fattorini G, Giovedí S, Melone M, Bosco F, Benfenati F, Conti F. Front Cell Neurosci. 2011; 5:32. Epub 2012 Jan 10.
Post-translational modifications and lipid binding profile of insect cell-expressed full-length mammalian synaptotagmin 1. [Biochemistry. 2011]
Post-translational modifications and lipid binding profile of insect cell-expressed full-length mammalian synaptotagmin 1.
Vrljic M, Strop P, Hill RC, Hansen KC, Chu S, Brunger AT. Biochemistry. 2011 Nov 22; 50(46):9998-10012. Epub 2011 Oct 26.
Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Stx1A and SNARE complex. [Mol Biol Cell. 2011]
Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Stx1A and SNARE complex.
Shi L, Kümmel D, Coleman J, Melia TJ, Giraudo CG. Mol Biol Cell. 2011 Nov; 22(21):4150-60. Epub 2011 Sep 7.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Protein Clusters
Clusters of related proteins from the Protein Clusters database that cite the current articles. Sources of references in Protein Clusters include the associated Gene and Conserved Domain records as well as NCBI added citations.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Domains
Conserved Domain Database (CDD) records that cite the current articles. Citations are from the CDD source database records (PFAM, SMART).
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Synaptotagmin: a calcium sensor on the synaptic vesicle surface.
Synaptotagmin: a calcium sensor on the synaptic vesicle surface.
Science. 1992 May 15 ;256(5059):1021-5.

PubMed
Celecoxib tolerability in patients with hypersensitivity (mainly cutaneous react...
Celecoxib tolerability in patients with hypersensitivity (mainly cutaneous reactions) to nonsteroidal anti-inflammatory drugs.
Int Arch Allergy Immunol. 2005 Jun ;137(2):145-50. Epub 2005 May 13 .

PubMed
Oncogenic forms of p53 inhibit p53-regulated gene expression.
Oncogenic forms of p53 inhibit p53-regulated gene expression.
Science. 1992 May 8 ;256(5058):827-30.

PubMed
A targeted mass spectrometric analysis of phosphatidylinositol phosphate species...
A targeted mass spectrometric analysis of phosphatidylinositol phosphate species.
J Lipid Res. 2005 Aug ;46(8):1796-802. Epub 2005 May 16 .

PubMed
Gaucher disease: new molecular approaches to diagnosis and treatment.
Gaucher disease: new molecular approaches to diagnosis and treatment.
Science. 1992 May 8 ;256(5058):794-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Synaptotagmin: a calcium sensor on the synaptic vesicle surface.

Source

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by over 100 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information