The HIN-200 family: more than interferon-inducible genes?

Exp Cell Res. 2005 Aug 1;308(1):1-17. doi: 10.1016/j.yexcr.2005.03.032.

Abstract

The HIN-200 family was initially grouped together based on their hemopoietic expression, interferon-inducibility, nuclear localization, and characteristic 200 amino-acid domains. In this review, we performed a comprehensive search of genome databases and determined the location of previously characterized and predicted genes within the human, mouse, and rat HIN-200 loci. Several novel proteins were predicted in the mouse and rat. We also discuss recent advances in our understanding of this family of proteins and highlight the most important findings. In addition to a role in interferon biology, there is now good evidence supporting a role for these proteins as regulators of cell proliferation and differentiation. The activity of HIN-200 proteins is not restricted to the hemopoietic system as they are expressed and can function in a variety of other cells and tissues. The importance of HIN-200 proteins in disease now is beginning to be understood as they appear to be involved in autoimmunity and may act as tumor suppressor proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cloning, Molecular
  • Databases, Genetic
  • Humans
  • Interferons / physiology*
  • Mice
  • Molecular Sequence Data
  • Nuclear Proteins* / chemistry
  • Nuclear Proteins* / genetics
  • Nuclear Proteins* / physiology
  • Rats
  • Sequence Alignment

Substances

  • HIN-200 protein, human
  • HIN-200 protein, mouse
  • HIN-200 protein, rat
  • Nuclear Proteins
  • Interferons