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Trends Biochem Sci. 2005 May;30(5):240-4.

The yeast Mediator complex and its regulation.

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  • 1Department of Medical Biochemistry, Umeå University, S-901 87 Umeå, Sweden.


The Mediator complex acts as a bridge, conveying regulatory information from enhancers and other control elements to the basal RNA polymerase II transcription machinery. Mediator is required for the regulated transcription of nearly all RNA polymerase II-dependent genes in Saccharomyces cerevisiae, and post-translational modifications of specific Mediator subunits can affect global patterns of gene transcription.

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