Send to:

Choose Destination
See comment in PubMed Commons below
Trends Biochem Sci. 2005 May;30(5):235-9.

Mediator and the mechanism of transcriptional activation.

Author information

  • 1Department of Structural Biology, Stanford School of Medicine, Stanford, CA 94305, USA.


Mediator was discovered because of its activity in a yeast RNA polymerase II (pol II) transcription system - it is needed for the system to respond to a transcriptional activator. Mediator is the central link in the enhancer-->activator-->Mediator-->pol II-->promoter pathway. The transduction of regulatory signals through this pathway is crucial for transcription of almost all pol II promoters in all eukaryote organisms.

[PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk