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Trends Biochem Sci. 2005 May;30(5):235-9.

Mediator and the mechanism of transcriptional activation.

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  • 1Department of Structural Biology, Stanford School of Medicine, Stanford, CA 94305, USA.


Mediator was discovered because of its activity in a yeast RNA polymerase II (pol II) transcription system - it is needed for the system to respond to a transcriptional activator. Mediator is the central link in the enhancer-->activator-->Mediator-->pol II-->promoter pathway. The transduction of regulatory signals through this pathway is crucial for transcription of almost all pol II promoters in all eukaryote organisms.

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