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Drug Discov Today. 2005 May 15;10(10):719-25.

The continuing evolution of shotgun proteomics.

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  • 1Stowers Institute for Medical Research, 1000 E. 50th St., Kansas City, MO 64110, USA.


Shotgun proteomics has emerged as a powerful approach for the analysis of complex protein mixtures, including biofluids, tissues, cells, organelles or protein complexes. Having evolved from the integration of chromatography and mass spectrometry, innovations in sample preparation, multidimensional chromatography, mass spectrometry and proteomic informatics continually facilitate, enable and challenge shotgun proteomics. As a result, shotgun proteomics continues to evolve and enable new areas of biological research, and is beginning to impact human disease diagnosis and therapeutic intervention.

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