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Mol Cell. 2005 May 13;18(4):399-402.

Eukaryotic transcription activation: right on target.

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  • Howard Hughes Medical Institute, Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA. michael.green@umassmed.edu


The unambiguous identification of the direct targets of eukaryotic transcriptional activators has been a major challenge in the field. Recently, the authentic targets of several yeast and mammalian activators have been determined, and the results of these studies have important implications for our understanding of transcriptional activation mechanisms.

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