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    Histochem Cell Biol. 2005 Jun;123(4-5):517-28. Epub 2005 May 12.

    Analysis of ABCC6 (MRP6) in normal human tissues.

    Beck K, Hayashi K, Dang K, Hayashi M, Boyd CD.

    Laboratory of Matrix Pathobiology, The Pacific Biomedical Research Center, University of Hawai'i, 1993 East-West Road, Honolulu, HI 96822, USA. k.beck@unsw.edu.au

    To determine the tissue distribution of the ABC transporter ABCC6 in normal human tissues, we analyzed tissue arrays for the presence of ABCC6 mRNA by in situ hybridization and ABCC6 protein by immunohistochemistry using the polyclonal antibody HB-6. We detected ABCC6 mRNA and protein in various epithelial cells of exocrine and endocrine tissues, such as acinar cells in the pancreas, mucosal cells of the intestine and follicular epithelial cells of the thyroid. We obtained a very strong immunostaining for enteroendocrine G cells in the stomach. In addition, ABCC6 mRNA and protein were present in most neurons of the brain, in alveolar macrophages in the lungs and lymphocytes in the lymph node. Immunohistochemisty using the monoclonal antibody M6II-31 confirmed the widespread tissue distribution of ABCC6. The physiological substrate(s) of ABCC6 are yet unknown, but we suggest that ABCC6 fulfills multiple functions in different tissues. The strong immunostaining for ABCC6 in G cells suggests that it plays an important role in these endocrine cells.

    PMID: 15889270 [PubMed - indexed for MEDLINE]

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      Thyroid is a hormone produced by the body. When taken correctly, thyroid is used to treat the symptoms of hypothyroidism (a condition where the thyroid gland does not produce enough thyroid hormone). Symptoms of hypothyr...

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