Bioorg Chem. 2005 Jun;33(3):149-58. Epub 2004 Dec 15.

Phosphoryl transfer by aminoglycoside 3'-phosphotransferases and manifestation of antibiotic resistance.

Source

Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.

Abstract

Transfer of the gamma-phosphoryl group from ATP to aminoglycoside antibiotics by aminoglycoside 3'-phosphotransferases is one of the most important reactions for manifestation of bacterial resistance to this class of antibiotics. This review article surveys the latest structural and mechanistic findings with these enzymes.

PMID:: 15888308; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Source of phosphate in the enzymic reaction as a point of distinction among aminoglycoside 2''-phosphotransferases. [J Biol Chem. 2009]
Source of phosphate in the enzymic reaction as a point of distinction among aminoglycoside 2''-phosphotransferases.
Toth M, Chow JW, Mobashery S, Vakulenko SB. J Biol Chem. 2009 Mar 13; 284(11):6690-6. Epub 2009 Jan 21.
An aminoglycoside microarray platform for directly monitoring and studying antibiotic resistance. [Biochemistry. 2007]
An aminoglycoside microarray platform for directly monitoring and studying antibiotic resistance.
Disney MD, Barrett OJ. Biochemistry. 2007 Oct 9; 46(40):11223-30. Epub 2007 Sep 15.
Hydrolysis of ATP by aminoglycoside 3'-phosphotransferases: an unexpected cost to bacteria for harboring an antibiotic resistance enzyme. [J Biol Chem. 2006]
Hydrolysis of ATP by aminoglycoside 3'-phosphotransferases: an unexpected cost to bacteria for harboring an antibiotic resistance enzyme.
Kim C, Cha JY, Yan H, Vakulenko SB, Mobashery S. J Biol Chem. 2006 Mar 17; 281(11):6964-9. Epub 2006 Jan 3.
Review Aminoglycoside antibiotic resistance by enzymatic deactivation. [Curr Drug Targets Infect Disor...]
Review Aminoglycoside antibiotic resistance by enzymatic deactivation.
Smith CA, Baker EN. Curr Drug Targets Infect Disord. 2002 Jun; 2(2):143-60.
Review Developing a snapshot of the ATP binding domain(s) of aminoglycoside phosphotransferases. [Front Biosci. 1999]
Review Developing a snapshot of the ATP binding domain(s) of aminoglycoside phosphotransferases.
Perlin MH, Brown SA, Dholakia JN. Front Biosci. 1999 Jan 1; 4:D63-71. Epub 1999 Jan 1.

See reviews... See all...

Cited by 4 PubMed Central articles

The crystal structures of substrate and nucleotide complexes of Enterococcus faecium aminoglycoside-2''-phosphotransferase-IIa [APH(2'')-IIa] provide insights into substrate selectivity in the APH(2'') subfamily. [J Bacteriol. 2009]
The crystal structures of substrate and nucleotide complexes of Enterococcus faecium aminoglycoside-2''-phosphotransferase-IIa [APH(2'')-IIa] provide insights into substrate selectivity in the APH(2'') subfamily.
Young PG, Walanj R, Lakshmi V, Byrnes LJ, Metcalf P, Baker EN, Vakulenko SB, Smith CA. J Bacteriol. 2009 Jul; 191(13):4133-43. Epub 2009 May 8.
Purification, crystallization and preliminary X-ray analysis of aminoglycoside-2''-phosphotransferase-Ic [APH(2'')-Ic] from Enterococcus gallinarum. [Acta Crystallogr Sect F Struct...]
Purification, crystallization and preliminary X-ray analysis of aminoglycoside-2''-phosphotransferase-Ic [APH(2'')-Ic] from Enterococcus gallinarum.
Byrnes LJ, Badarau A, Vakulenko SB, Smith CA. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Feb 1; 64(Pt 2):126-9. Epub 2008 Jan 31.
Molecular determinants of antibiotic recognition and resistance by aminoglycoside phosphotransferase (3')-IIIa: a calorimetric and mutational analysis. [J Mol Biol. 2007]
Molecular determinants of antibiotic recognition and resistance by aminoglycoside phosphotransferase (3')-IIIa: a calorimetric and mutational analysis.
Kaul M, Barbieri CM, Srinivasan AR, Pilch DS. J Mol Biol. 2007 May 25; 369(1):142-56. Epub 2007 Mar 15.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Protein Clusters
Clusters of related proteins from the Protein Clusters database that cite the current articles. Sources of references in Protein Clusters include the associated Gene and Conserved Domain records as well as NCBI added citations.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Domains
Conserved Domain Database (CDD) records that cite the current articles. Citations are from the CDD source database records (PFAM, SMART).
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Phosphoryl transfer by aminoglycoside 3'-phosphotransferases and manifestation o...
Phosphoryl transfer by aminoglycoside 3'-phosphotransferases and manifestation of antibiotic resistance.
Bioorg Chem. 2005 Jun ;33(3):149-58. Epub 2004 Dec 15 .

PubMed
Adherence to heart-healthy behaviors in a sample of the U.S. population.
Adherence to heart-healthy behaviors in a sample of the U.S. population.
Prev Chronic Dis. 2005 Apr ;2(2):A18. Epub 2005 Mar 15 .

PubMed
Blazing a trail: a public health research agenda in genomics and chronic disease...
Blazing a trail: a public health research agenda in genomics and chronic disease.
Prev Chronic Dis. 2005 Apr ;2(2):A04. Epub 2005 Mar 15 .

PubMed
Phototherapy and photochemotherapy of sclerosing skin diseases.
Phototherapy and photochemotherapy of sclerosing skin diseases.
Photodermatol Photoimmunol Photomed. 2005 Jun ;21(3):157-65.

PubMed
How Finsen's light cured lupus vulgaris.
How Finsen's light cured lupus vulgaris.
Photodermatol Photoimmunol Photomed. 2005 Jun ;21(3):118-24.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: